Bioactive Small Molecules
Selleck Chemical LLC BI-4020 S8921-1MG
BI-4020 is an orally active non-covalent EGFR inhibitor with IC50 of 0 6 nM and 0 2 nM for EGFRdel19 T790M C797S as biomarker potency and anti-proliferation potency in BaF3 cells respectively
Selleck Chemical LLC GNE-9815-E1079-25MG
GNE-9815 is a highly selective pan-Raf inhibitor with good oral bioavailability GNE-9815 exhibits Ki values of 0 062 and 0 19 nM for c-Raf and b-Raf respectively
Medchemexpress LLC Fluorescein O,O′-diacrylate | 7262-39-7 | 99.4% | 440.40 | 50 MG
Fluorescein O,O′-diacrylate | 7262-39-7 | 99.4% | 440.40 | 50 MG
Cayman Chemical ANTIBODY CytarabIn 500mg
A nucleoside analog and prodrug form of ara-CTP; triphosphorylated to ara-CTP by the successive actions of deoxycytidine kinase, deoxycytidylate kinase, and nucleoside diphosphate kinase; inhibits proliferation of HL-60, ML-1, Raji, and Jurkat human leukemia cell lines (IC50s = 37, 17, 16, and 72 nM, respectively); induces cell cycle arrest at the G0/G1 phase in HL-60 cells at 2.5 and 15 µM; reduces tumor growth and increases tumor caspase-3 activity in an MOLM-13 mouse xenograft model at 75 mg/kg per day intraperitoneally; increases survival and reduces brain herpesvirus titers in infected rats at 80 and 320 mg/kg subcutaneously
Medchemexpress LLC Vitamin A Propionate | 7069-42-3 | 98.9% | 342.51 | 100 MG
Vitamin A Propionate is an ester compound of vitamin A. In nutritional studies of foals, different doses have different effects on growth, serum biochemistry, and hematological indicators. Too high or too low doses can produce adverse effects related to the vitamin A concentration in plasma, liver, and kidneys.
- Appearance: Oil
- Color: Colorless to light yellow
- Shipping: Room temperature in continental US; may vary elsewhere.
- Storage: Pure form -20°C 3 years; In solvent -80°C 6 months, -20°C 1 month.
Medchemexpress LLC Soya Lecithin | 8030-76-0 | 50 G
Soya Lecithin is a phospholipid mixture that functions as a drug delivery vehicle and a pharmaceutical excipient. It can self-assemble to form a lipid bilayer structure with amphiphilic properties, possessing both a hydrophilic head and a hydrophobic tail. This characteristic allows it to encapsulate hydrophobic drugs and form stable nanoliposomes or microemulsions, improving the solubility and cellular uptake efficiency of poorly soluble drugs.
- Functions as a drug delivery vehicle and pharmaceutical excipient
- Forms lipid bilayer structures through self-assembly
- Amphiphilic properties, enabling encapsulation of hydrophobic drugs
- Forms stable nanoliposomes or microemulsions
- Improves solubility and cellular uptake efficiency of poorly soluble drugs
- Enhances drug delivery and regulates cell proliferation
- Promotes proliferation of rat bone marrow mesenchymal stem cells (rBMSCs)
Selleck Chemical LLC Sapropterin S9568-5MG
Sapropterin (Tetrahydrobiopterin) Dihydrochloride a synthetic preparation of the dihydrochloride salt of naturally occurring tetrahydrobiopterin (BH4) is a phenylalanine hydroxylase activator
Apexbio Technology LLC CZC24832 1159824-67-5 5mg
CZC24832 (CAS 1159824-67-5) is a selective small-molecule inhibitor of phosphoinositide 3-kinase gamma (PI3K ) a member of the class I PI3K family involved in the regulation of cellular processes such as growth differentiation survival and migration Through high-throughput chemoproteomic profiling CZC24832 was identified as a tool compound to dissect PI3K function In vitro studies demonstrate that CZC24832 specifically inhibits PI3K -mediated signaling pathways notably modulating differentiation of T helper 17 (TH17) cells and reducing interleukin-17 production In vivo the compound exhibits activity in models of inflammation indicating its utility in investigating the role of PI3K in immune-mediated and inflammatory diseases
Cayman Chemical cIs-6-HexadecenoIc AcId 5mg
A monounsaturated fatty acid; one of the primary fatty acids in human skin; levels are increased in isolated sebum from the face and back of patients with acne; levels are decreased in the non-lesional skin and isolated sebum of atopic dermatitis patients; active against S. aureus in vitro at 5 UG/ml at pH 5.5
Medchemexpress LLC Fmoc-Lys(Z)-OH | 86060-82-4 | 99.53% | 502.56 | 100 G
Fmoc-Lys(Z)-OH | 86060-82-4 | 99.53% | 502.56 | 100 G
Medchemexpress LLC GALK1-IN-1 | 669718-48-3 | 98.2% | 1 MG
GALK1-IN-1 (Compound 4) is a galactokinase inhibitor with an IC50 of 4.2129 μM. It is for research use only and not sold to patients.
Ace Glass, Inc. 80mm Ace-Thred UHMWP bushing, -336 FETFE O-ring, accepts80mm OD tubing
80MM -336 UHMWP BUSHING
Cayman Chemical 5-trns ProstaglndIn E2 5mg
5-trans PGE2 occurs naturally in some gorgonian corals and is a common impurity in commercial lots of PGE1.{2213} It is 18 times more potent than PGE2 in activating adenylate cyclase in NCB-20 cell homogenates.{2180} 5-trans PGE2 accelerates fibrinolysis by enhancing plasminogen activation mediated by tissue-type plasminogen activator.{2177} It also inhibits platelet aggregation in human PRP with an IC50 of 180 nM.{1607}
Medchemexpress LLC Chitin synthase inhibitor 4 | 2755847-31-3 | C20H15FN4O | 5 MG
Chitin synthase inhibitor 4 (compound 4fh) is a chitin synthase inhibitor with fungicidal effect. It is a potential chitin synthase-based fungicide in agriculture.
- Shows good antifungal activities against V. mali and S. sclerotiorum with EC50 values of 0.71 and 2.47 μg/mL.
- Displays potency inhibition against V. mali and S. sclerotiorum with inhibition rates of 90.3% and 88.7% (at 50 μg/mL).
- Blocks hyphae growth, resulting in abnormal growth, decreased cell content, cell wall degradation, and plasmolysis (at 1 μg/mL).
- Exhibits inhibition against chitin synthase and polyoxin D with inhibition rates of 68.08% and 63.84% (at 50 μM; 3 h).
- Has considerable curative and protective effects against S. sclerotiorum vivo, and no obvious phytotoxicity (at 50 μg/mL).
- Has low acute toxicity, with no carcinogenic and mutagenic toxicity risk.